Analysis of the functions of a novel class of ubiquitin E3 Ligases in TNF signalling in vivo

该项目的目的是发现一种新的泛素连接酶复合物调节TNF超家族信号的作用。它将增加对TNF通路的理解，提高我们在药理学上操纵它的能力，或者以其他方式，在大量衰弱的人类疾病中，包括类风湿关节炎和克罗恩病，这些疾病是由异常TNF信号引起的。由于TNF在肿瘤发生中的作用，它也可能有助于新的抗癌治疗。

The aim of this project to discover the role of a novel ubiquitin ligase complex that regulates TNF superfamily signalling. It will increase understanding of the TNF pathway and improve our ability to manipulate it pharmacologically, or otherwise, in the large number of debilitating human diseases including Rheumatoid Arthritis and Crohn's disease that result from aberrant TNF signalling. Because of the role of TNF in tumorigenesis it may also contribute to novel anti-cancer treatments.