The clinical significance of sex hormone crosstalk in estrogen receptor positive breast cancer.
The clinical significance of sex hormone crosstalk in estrogen receptor positive breast cancer.
批准号:
nhmrc : 1130077
负责人:
A/Pr Elgene Lim
金额:
$68.95万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2017
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2017-01-01 至 2020-12-31
中文摘要
乳腺癌主要是性激素雌激素刺激失控生长的一种疾病。我们最近发现,包括黄体酮和雄激素在内的其他性激素可以改变雌激素在乳腺癌中的作用,阻止乳腺癌的生长或使肿瘤消失。这项研究将研究这三种性激素之间复杂的相互作用,以开发新的、更有效的治疗乳腺癌的策略。
英文摘要
Breast cancer is mainly a disease in which the sex hormone estrogen stimulates uncontrolled growth. We have recently discovered that other sex hormones, including progesterone and androgen, can redirect the actions of estrogen in breast cancers to halt growth or make a tumour disappear. This study will examine the complex interaction between all three sex hormones to develop new, more effective strategies for treating breast cancer.
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会议论文
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Development of a novel and highly selective CDK4/6 inhibitor for treating cancer
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The clinical significance of sex hormone crosstalk in estrogen receptor positive breast cancer.
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Development of vinorelbine as a tablet based therapy to cure ectopic pregnancies
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资助金额:$24.68万
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Four dimensional epigenome remodelling: implications for endocrine resistance in breast cancer
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Targeting the Oncoprotein MDMX as a Novel Treatment for Triple Negative Breast Cancer
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资助金额:$56.17万
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依托单位:
The identification of novel targets and therapeutic agents in the treatment of triple negative breast cancer.
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批准号:nhmrc : 1013525
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项目类别:Early Career Fellowships
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资助金额:$24.4万
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财政年份:2011
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负责人:A/Pr Elgene Lim
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依托单位:
海外基金