The effect of Cytochrome P450 genotype on blood pressure and 20-HETE responses to lifestyle interventions
The effect of Cytochrome P450 genotype on blood pressure and 20-HETE responses to lifestyle interventions
批准号:
nhmrc : 634359
负责人:
Dr Natalie Ward
金额:
$49.59万
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2010
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2010-01-01 至 2013-12-31
中文摘要
降低心脏病风险的治疗效果在不同的人之间可能有很大差异。这在一定程度上是由于一个人的基因构成。被称为花生四烯酸细胞色素P450代谢物的脂肪酸代谢产物(CYP450-AAM)可以作用于血管和肾脏来调节血压。我们将研究调节CYP450-AAM的基因变异与高盐饮食或减肥相结合对血压和心脏病风险的影响。
英文摘要
The effectiveness of treatments to reduce heart disease risk can vary enormously between individuals. This is partly due to a persons genetic makeup. Fatty acid metabolites called cytochrome P450 metabolites of arachidonic acid (CYP450-AAM) can act on blood vessels and the kidney to regulate blood pressure. We will study the effect of having a variation in a gene that regulates CYP450-AAM on blood pressure and heart disease risk in combination with a high salt diet or weight reduction.
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