The effect of innate immune responses on the induction of protective immunity in murine typhoid fever

沙门氏菌是人类的重要病原体，可引起胃肠炎、伤寒和关节炎等疾病。与大多数(如果不是所有的)感染一样，宿主和细菌之间的早期相互作用具有非常非特异性的症状。这些非特异性症状的出现是因为感染激活了所谓的先天免疫系统。这笔赠款的目的是确定这些由称为细胞因子的免疫原释放引起的非特异性症状是否对发展有效的免疫反应至关重要，从而防止随后的再次感染。这项研究对疫苗、我们理解细菌如何致病以及先天免疫系统在免疫发展中的作用和能力都有重要的意义。

Salmonella are important pathogens of humans causing diseases ranging from gastroenteritis, typhoid fever to arthritis. Like most if not all infections, the early interaction between the host and the bacterium is characterised by very non-specific symptoms. These non-specific symptoms arise because the so-called innate immune system is activated by the infection. The purpose of this grant is to establish whether these non-specific symptoms, caused by the release of immunological homrones called cytokines, are essential to the development of an effective immune response which can protect against subsequent re-infection. This study has important implications for vaccines, of our understanding of how bacteria cause disease, and the role-capacity of the innate immune system in the development of immunity.