The link between regional lung stretch and distal organ injury in response to mechanical ventilation

急性呼吸窘迫综合征（ARDS）和急性肺损伤（ALI）的死亡率很高（超过30%）。不幸的是，机械通气，一种挽救生命的干预措施导致了这种高死亡率。有趣的是，这些重症患者中很少有人死于缺氧，绝大多数死于“非肺”器官衰竭。在这项研究中，我们将探讨机械通气与器官衰竭的机制，以期提高死亡率。

Acute respiratory distress syndrome (ARDS) and acute lung injury (ALI) have very high mortality rates (over 30%). Unfortunately, mechanical ventilation, a life-saving intervention contributes to this high mortality. Interestingly, very few of these critically ill patients die from a lack of oxygen with the vast majority dying from 'non-lung' organ failure. In this study we will investigate the mechanisms linking mechanical ventilation with organ failure with a view to improving mortality.