The magic shield of the human uterus and fate of embryo implantation

胚胎植入是确定妊娠的关键步骤，也是体外受精治疗克服不孕症的主要障碍。子宫必须进行相当大的改造，才能“接受”胚胎的植入。然而，人类子宫如何发展这种接受能力还不是很清楚，这种知识差距严重阻碍了试管受精治疗。本项目将研究一种控制人类子宫容受性的新型子宫屏障及其在提高体外受精成功率方面的临床应用。

Embryo implantation is a critical step in establishing pregnancy and a major hurdle in IVF treatment to overcome infertility. The uterus must remodel considerably to become “receptive” for an embryo to implant. However, how the human uterus develops this receptivity is not well understood and this knowledge gap severely hampers IVF treatment. This project will investigate a novel uterine shield controlling human uterine receptivity and its clinical application in improving IVF success rates.