The Microniche: A novel in-vitro and in-vivo prostate cancer model system

在体外维持原发性前列腺癌细胞（PCa）仍然是该领域的一个巨大挑战，这阻碍了系统地表征细胞行为和量化药物反应的努力。我们的团队最近开发了一种3-痴呆（3D）类器官培养系统，可以在体外维持前列腺癌，在这里，我们将把这项技术与我们的3D骨基质模型系统相结合，以更好地表征前列腺癌骨转移并确定新的临床治疗方案。

Maintaining primary prostate cancer cells (PCa) in vitro remains an enormous challenge for the field, and this obstructs efforts to systematically characterize cell behaviour and quantify drug response. Our group recently developed a 3-demsensional (3D) organoid culture system that does maintain PCa in vitro, and here we will integrate this technology with our 3D bone maorrow niche model system to better characterize PCa bone metastases and identify new clinical treatment regimes.