Antigen receptor as oncogene: understanding CARD11 mutations in B cell malignancy

超过5000名澳大利亚人被新诊断为淋巴瘤。最近的技术发现了许多淋巴瘤的候选基因，但仍然不清楚每个突变的基因如何扭曲肿瘤细胞内的信号分子。通过将一种反复突变的基因CARD11引入小鼠B细胞，我们将研究这种突变如何影响正常的信号通路和B细胞功能。我们希望这个项目将为使用即将到来的药物靶向特定分子提供指导。

More than 5000 Australians are newly diagnosed as lymphomas. Recent technology identified many candidate genes for lymphomas, however it still remains unclear how each mutated gene distorts signalling molecules inside tumours cells. By introducing one of recurrent mutated genes, CARD11 into mouse B cells, we will examine how this mutation affects normal signalling pathways and B cell functions. We hope this project will provide a guidance to use forthcoming drugs to target specific molecules.