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Antioxidant enzymes counter reactive oxygen species from steroidogenic cytochrome P450 enzymes in the ovary to limit aneuploidy of embryos

Antioxidant enzymes counter reactive oxygen species from steroidogenic cytochrome P450 enzymes in the ovary to limit aneuploidy of embryos
抗氧化酶对抗卵巢中类固醇生成细胞色素 P450 酶的活性氧,以限制胚胎的非整倍性
批准号:
nhmrc : GNT1143289
负责人:
A/Pr Elizabeth New
金额:
$53.7万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2018
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2018-01-01 至 --

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中文摘要
翻译
许多出生缺陷是由于排卵前卵子受损造成的。衰老会造成更大的损害,因此建议早点生孩子。然而,我们相信我们已经确定了在排卵前几周卵泡发育后期发生损害的来源。证明这一点将使我们能够确定鸡蛋何时面临最大的损害风险,并设计出降低风险的策略。
英文摘要
Many birth defects are due to damage sustained by the eggs before ovulation. Aging allows more damage, hence the advice to have babies earlier in life. However, we believe we have identified a source of damage that happens during late development of the follicle in the weeks before ovulation. Proving this will enable us define when an egg is most at risk of damage and to devise strategies to lower the risk.
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