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Antioxidant enzymes counter reactive oxygen species from steroidogenic cytochrome P450 enzymes in the ovary to limit aneuploidy of embryos

Antioxidant enzymes counter reactive oxygen species from steroidogenic cytochrome P450 enzymes in the ovary to limit aneuploidy of embryos
抗氧化酶对抗卵巢中类固醇生成细胞色素 P450 酶的活性氧，以限制胚胎的非整倍性
批准号：
nhmrc : 1143289
负责人：
Prof Hugh Harris
金额：
$36.31万
依托单位：
The University of Adelaide
依托单位国家：
澳大利亚
项目类别：
Project Grants
财政年份：
2018
资助国家：
澳大利亚
项目状态：
已结题
起止时间：
2018-01-01 至 2020-12-31
来源：
https://researchdata.edu.au/antioxidant-enzymes-counter-aneuploidy-embryos/1319917
关键词：
Antioxidantenzymescounterreactiveoxygen

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英文摘要
Many birth defects are due to damage sustained by the eggs before ovulation. Aging allows more damage, hence the advice to have babies earlier in life. However, we believe we have identified a source of damage that happens during late development of the follicle in the weeks before ovulation. Proving this will enable us define when an egg is most at risk of damage and to devise strategies to lower the risk.
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Visualising molecular level detail in single cells and intact tissues
  • 批准号：
    DP210102148
  • 项目类别：
    Discovery Projects
  • 资助金额：
    $29.84万
  • 财政年份：
    2021
  • 负责人：
    Prof Hugh Harris
  • 依托单位：
    The University of Adelaide
Characterisation of the beneficial vs toxic forms of selenium in the diet
  • 批准号：
    DP200102670
  • 项目类别：
    Discovery Projects
  • 资助金额：
    $32.31万
  • 财政年份：
    2020
  • 负责人：
    Prof Hugh Harris
  • 依托单位：
    The University of Adelaide
The fate of dietary selenium in vivo; a direct approach to linking chemical form with biological activity.
  • 批准号：
    DP0985807
  • 项目类别：
    Discovery Projects
  • 资助金额：
    $57.75万
  • 财政年份：
    2009
  • 负责人：
    Prof Hugh Harris
  • 依托单位：
    The University of Adelaide
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