To determine whether Myc-driven transformation in haematopoietic cell lineages is dependent on high-levels of Myc protein expression.

Myc是一种必需的细胞蛋白，但也是多种组织中癌症的常见驱动因素。在血液癌症中，Myc经常过度表达。相比之下，Myc在早期实体癌中很少过表达，尽管在晚期阶段通常水平升高。我们将采用独特的癌症模型，其中Myc可以在血细胞发育期间的不同时间以不同的设定水平激活，以解决不同水平的Myc在血液癌症演变中的具体贡献。

Myc is an essential cellular protein but is also a common drive of cancer in multiple tissues. In blood cancers Myc is frequently overexpressed. In contrast, Myc is rarely overexpressed in early stage solid cancers, although often elevated levels at later stages. We will employ unique models of cancer in which Myc can be activated at different set levels at different times during blood cell development to address what the specific contributions of different levels of Myc are in the evolution of blood cancers.