Asthma prevention and treatment using UVB radiation-induced immunomodulation

尽管采用了现代昂贵的药物，哮喘的患病率仍在增加。我们的研究表明，皮肤暴露在阳光中发现的波长的UVB辐射的红斑剂量下，可以抑制对呼吸道中遇到的过敏原的反应。我们正在请求支持在小鼠身上研究暴露在剃毛背部的UVB辐射可以减少过敏原暴露时呼吸道粘膜的炎症的机制。UVB辐射的全身免疫调节作用以前已经被描述过，但还没有被科学地与哮喘的发生联系起来。这是一个非常新和新颖的研究领域，支持了一个世纪以来的轶事报道，即在海滩和山区度假胜地度假与增加UVB暴露有关对哮喘治疗有益。这是原则性学习的证明。如果我们能够证实UVB具有免疫调节作用，并更好地了解UVB抑制呼吸道炎症的机制，我们将研究非致癌的、由UVB诱导的皮肤来源的中间分子是否具有同样的调节作用。

The prevalence of asthma is increasing despite the adoption of modern expensive drugs. Our studies suggest that exposure of skin to an erythemal dose of the wavelengths of UVB radiation found in sunlight can suppress responses to allergens encountered in the airways. We are requesting support to study the mechanisms in mice by which exposure to UVB radiation on their shaved backs can reduce inflammation in the airway mucosa upon allergen exposure. Whole body immunomodulatory effects of UVB radiation have been previously described but have not been scientifically linked with asthma development. This is a very new and novel research area which supports century-old anecdotal reports that holidays at beach and mountain resorts associated with increased UVB exposure are beneficial in asthma treatment. This is a proof of principle study. If we can confirm that UVB is immunomodulatory and better understand the mechanisms by which UVB suppresses inflammation in the airways, we will investigate the potential of non-carcinogenic, UVB-induced, skin-derived intermediary molecules to have the same regulatory effects.