Regulated shuttling of beta-catenin and IQGAP1 between nucleus and plasma membrane in migrating cells

导致结肠癌的遗传基因突变每年导致4700名澳大利亚人死亡。大约每21个澳大利亚人中就有一个在75岁之前患上结肠直肠癌。-连环蛋白的激活是结肠癌发生过程中的一个关键开关。我们发现-连环蛋白和与之相互作用的另一种叫做IQGAP1的蛋白质在不同的细胞区室之间移动。我们计划更详细地研究这一过程，因为它与β -连环蛋白如何起作用以及了解它在癌症中的作用有关。

Inherited gene mutations that cause colon cancer kill 4,700 Australians every year. About 1 in 21 Australians develop colorectal cancer by age 75. Activation of the beta-catenin protein is a critical switch in the path to colon cancer. We discovered that beta-catenin, and another protein it interacts with called IQGAP1, move between different cellular compartments. We plan to study this process in more detail, as it relates to how beta-catenin works and to understanding its role in cancer.