A Long-Lasting Oral Drug Delivery System Using Spiky Silica Nanoparticles

该项目旨在开发一种新型的基于二氧化硅纳米颗粒的长效口服药物递送系统。这些颗粒将被设计成尖尖的形态，这将增加对胃肠道的附着力，从而使药物持续释放数天甚至数周。更持久的口服药物配方将使患者更容易坚持治疗艾滋病等慢性疾病所需的治疗计划，并提高治疗的有效性。

This project aims to develop a novel silica nanoparticle-based delivery system for long-lasting oral drug delivery. The particles will be engineered with a spiky morphology that will increase adhesion to the gastrointestinal tract enabling sustained drug release for days or even weeks. Longer lasting oral drug formulations would make it much easier for patients to adhere to the treatment schedules required in chronic diseases like HIV and increase the effectiveness of therapy.