Bad Bugs Need Drugs: combating antibiotic resistance caused by bacterial ‘superbugs’

细菌“超级细菌”是一个重大的全球医学挑战。“老的”多粘菌素是对抗革兰氏阴性“超级细菌”的唯一抗生素，但现有的药理信息有限。在接下来的5年里，作为一名药理学家，我将继续重新开发多粘菌素，并发现针对这些问题细菌的新抗生素。我的研究针对的是美国传染病学会和世界卫生组织强调的“坏虫子，没有毒品”的灾难。

Bacterial ‘superbugs’ present a significant global medical challenge. ‘Old’ polymyxins are the only antibiotics against Gram-negative ‘superbugs’ but with limited pharmacological information available. In the next 5 years, as a pharmacologist I will continue re-developing polymyxins and discovering novel antibiotics against these problematic bacteria. My research targets the “Bad Bugs, No Drugs” disaster highlighted by the Infectious Diseases Society of America and the World Health Organization.