Bench to beside translational studies to develop treatments for preeclampsia

先兆子痫是一种常见的、破坏性的妊娠并发症，导致无数母亲和婴儿死亡。没有医疗救治。令人兴奋的是，我们已经确定了两种孕期安全的药物：二甲双胍和柳氮磺胺吡啶，它们可能治疗这种疾病。我们计划将这些药物引入临床，看看它们是否可能是治疗先兆子痫的有效方法。如果成功，这些药物有可能改善全球妇女和婴儿的生活。

Preeclampsia is a common, devastating complication of pregnancy responsible for the loss of countless mothers and babies. There is no medical treatment. Excitingly we have identified 2 medications, safe in pregnancy: metformin and sulfasalazine that may treat this disease. We plan to introduce these medications into the clinic to see whether they may be an effective treatment for preeclampsia. If successful, these medications have the potential to improve the lives of women and babies globally.