Equipment for quantitive real-time gene expression analysis

这笔拨款用于购买仪器，这些仪器将由四个高度活跃的研究实验室共享，以研究各种重要细菌病原体的基因表达和基因调控。该设备将允许这些研究人员测量参与疾病过程的某些基因的活跃程度。该提案涵盖的细菌包括导致“链球菌性咽炎和食肉性疾病”的病原体（化脓性链球菌），主要胃肠道病原体（幽门螺杆菌和空肠弯曲杆菌），多种抗生素耐药细菌（金黄色葡萄球菌）和导致囊性纤维化患者非常危险的肺炎的微生物（洋葱伯克霍氏菌）。这4名研究人员的研究成果有望引领细菌性疾病的替代治疗方法。

This grant is to acquire instrumentation that will be shared by four highly active research laboratories to study gene expression and gene regulation in various important bacterial pathogens. The equipment will allow these researchers to measure how active certain genes are that are involved in the disease process. The bacteria covered in this proposal include pathogens that cause both "strep-throat and flesh eating disease (Streptococcus pyogenes), major gastrointestinal pathogens (Helicobacter pylori and Campylobacter jejuni), multiple antibiotic resistant bacteria (Staphylococcus aureus) and organisms that cause a very dangerous pneumonia in cystic fibrosis patients (Burkholderia cepacia). The research produced from these four investigators is expected to lead to alternative treatment methods for bacterial diseases.