Biomechanics meets Phenomics: Towards understanding and predicting abdominal aortic aneurysm (AAA) disease progression

决定是否对腹主动脉瘤（AAA）进行手术的标准是基于最大直径，而没有考虑到特定患者的破裂风险。通过结合影像学、计算生物力学和代谢表型，我们将评估AAA的结构完整性和系统性反应的局部结构变化。这将有助于更好地区分破裂风险，为患者带来更好的结果，并为卫生系统节省资金。

The criterion used to decide whether to operate on an abdominal aortic aneurysm (AAA), based on the maximum diameter, does not take into consideration the rupture risk for a given patient. By combining imaging, computational biomechanics and metabolic phenotyping, we will assess the structural integrity of an AAA and local structural changes of systemic response. These will allow improved differentiation of rupture risk, leading to better outcomes for patients and savings for the health system.