Brain Oxygen Neuromonitoring In Australia And New Zealand Assessment (BONANZA) Trial

在澳大利亚，严重创伤性脑损伤是导致死亡和残疾的主要原因。在这种情况下，重症监护的重点是确保向受伤的大脑提供足够的氧气，尽管目前的管理可能并不总是做到这一点。我们将随机将860名严重脑损伤患者分配到标准护理或通过早期脑组织氧监测告知的新管理方案。这一战略有望带来更好的功能结果和重大节省。

Severe traumatic brain injury is a leading cause of death and disability in Australia. Intensive care in this setting focuses on ensuring adequate delivery of oxygen to the injured brain, albeit current management may not always achieve this. We will randomly allocate 860 severely brain injured patients to either standard care, or a novel management protocol informed by early brain tissue oxygen monitoring. This strategy will hopefully lead to improved functional outcomes and major savings.