Capsule Synthesis and Tyrosine Phosphorylation in Streptococcus pneumoniae

肺炎链球菌在世界范围内引起大量的发病率和死亡率。抗生素耐药性和疫苗接种是个问题。需要新的抗感染药物。我们将研究调节多糖胶囊合成的蛋白质（CpsB, CpsC, CpsD），以了解它们之间的相互作用，并确定抑制CpsB和CpsD的药物。我们还将研究酪氨酸磷酸化在细菌中的更广泛作用，并研究这与胶囊合成的交叉。

The bacterium Streptococcus pneumoniae causes much morbidity and mortality worldwide. Antibiotic resistance and vaccination is problematic. New anti-infectives are required. We will study proteins (CpsB, CpsC, CpsD) that regulate polysaccharide capsule synthesis to understand their interactions, and to identify drugs that inhibit CpsB and CpsD. We will also investigate the wider role of tyrosine phosphorylation in the bacterium and investigate how this intersects with capsule synthesis.