Glycan-glycan interactions between bacterial pathogens and host cells: A novel mechanism of bacterial adherence, a new opportunity for strategies to treat and prevent disease and a new paradigm in interactions between macromolecules.

细菌病原体与宿主细胞之间的聚糖-聚糖相互作用：细菌粘附的新机制、治疗和预防疾病策略的新机会以及大分子之间相互作用的新范例。

• 批准号: nhmrc : GNT1108124
• 负责人: A/Pr Renato Morona
• 金额: $ 105.93万
• 依托单位: Griffith University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/glycan-glycan-interactions-interactions-macromolecules/1346628
• 关键词: Glycan; glycan; interactions; between; bacterial

Cell surface carbohydrates are ubiquitous throughout nature. Human cell surface carbohydrates are specifically targeted by microbial proteins. These interactions are crucial in causing disease. We have recently shown that the carbohydrates on our cells and those on pathogenic bacteria can interact with one another. Understanding the nature and role of these newly discovered interactions may lead to strategies to block them via new drugs and vaccines.

细胞表面碳水化合物在自然界中普遍存在。人类细胞表面的碳水化合物是微生物蛋白质的特异性靶向。这些相互作用在引起疾病方面至关重要。我们最近已经证明，我们细胞上的碳水化合物和致病细菌上的碳水化合物可以相互作用。了解这些新发现的相互作用的性质和作用可能会导致通过新药和疫苗阻断它们的策略。