Glycan-glycan interactions between bacterial pathogens and host cells: A novel mechanism of bacterial adherence, a new opportunity for strategies to treat and prevent disease and a new paradigm in interactions between macromolecules.
Glycan-glycan interactions between bacterial pathogens and host cells: A novel mechanism of bacterial adherence, a new opportunity for strategies to treat and prevent disease and a new paradigm in interactions between macromolecules.
批准号:
nhmrc : 1108124
负责人:
A/Pr Renato Morona
金额:
$72.91万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2016
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2016-01-01 至 2019-12-31
中文摘要
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英文摘要
Cell surface carbohydrates are ubiquitous throughout nature. Human cell surface carbohydrates are specifically targeted by microbial proteins. These interactions are crucial in causing disease. We have recently shown that the carbohydrates on our cells and those on pathogenic bacteria can interact with one another. Understanding the nature and role of these newly discovered interactions may lead to strategies to block them via new drugs and vaccines.
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Glycan-glycan interactions between bacterial pathogens and host cells: A novel mechanism of bacterial adherence, a new opportunity for strategies to treat and prevent disease and a new paradigm in interactions between macromolecules.
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批准号:nhmrc : GNT1108124
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项目类别:Project Grants
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资助金额:$105.93万
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财政年份:2016
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负责人:A/Pr Renato Morona
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依托单位:
Capsule Synthesis and Tyrosine Phosphorylation in Streptococcus pneumoniae
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批准号:nhmrc : 1048749
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项目类别:Project Grants
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资助金额:$39.19万
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财政年份:2013
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负责人:A/Pr Renato Morona
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依托单位:
Pathogenesis, treatment and prevention of bacterial infectious diseases
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批准号:nhmrc : 565526
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项目类别:Programs
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资助金额:$650.27万
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财政年份:2009
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负责人:A/Pr Renato Morona
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依托单位:
Intra- and intercellular spreading in Shigella pathogenesis
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批准号:nhmrc : 565377
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项目类别:NHMRC Project Grants
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资助金额:$14.42万
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财政年份:2009
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负责人:A/Pr Renato Morona
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依托单位:
Proof of concept studies on a novel class of antibiotics
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批准号:nhmrc : 565506
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项目类别:NHMRC Development Grants
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资助金额:$13.32万
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财政年份:2009
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负责人:A/Pr Renato Morona
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依托单位:
The Molecular basis of bacterial infectious diseases
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批准号:nhmrc : 284214
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项目类别:Programs
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资助金额:$1082.28万
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财政年份:2003
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负责人:A/Pr Renato Morona
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依托单位:
Recombinant bacteria expressing oligosaccharide receptor mimics for prevention of enteric infections
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批准号:nhmrc : 250355
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项目类别:NHMRC Development Grants
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资助金额:$30.08万
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财政年份:2002
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负责人:A/Pr Renato Morona
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依托单位:
Shigella flexneri O antigen polysaccharides: biosynthesis, function in virulence, and interaction with IcsA/VirG
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批准号:nhmrc : 157946
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项目类别:NHMRC Project Grants
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资助金额:$31.21万
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财政年份:2001
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负责人:A/Pr Renato Morona
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依托单位:
GENETIC ANALYSIS OF POLYSACCHARIDE CAPSULE BIOSYNTHESIS AND REGULATION IN STREPTOCOCCUS PNEUMONIAE
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批准号:nhmrc : 157923
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项目类别:NHMRC Project Grants
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资助金额:$25.14万
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财政年份:2001
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负责人:A/Pr Renato Morona
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依托单位:
The role of lipopolysaccharide O-antigen in the intracellular lifestyle of shigella flexneri
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批准号:nhmrc : 980160
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项目类别:NHMRC Project Grants
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资助金额:$26.52万
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财政年份:1998
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负责人:A/Pr Renato Morona
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依托单位:
国内基金
海外基金
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批准号:21877063
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项目类别:面上项目
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资助金额:61.4万元
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依托单位:
糖药物蛋白Interferonβ N-glycan的均一、人源化改造
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批准号:81102361
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肠道粘蛋白分子不同O型糖基化调节病原体与肠粘液屏障作用的分子机制研究
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项目类别:面上项目
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资助金额:60.0万元
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批准年份:2011
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负责人:汪荣泉
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依托单位:
发现胰腺癌血清O-连接聚糖生物标记物的新方法
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批准号:30900254
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项目类别:青年科学基金项目
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资助金额:20.0万元
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批准年份:2009
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