Mathematical modeling of multicellular organization of epithelial tissues

这个项目将使用数学建模和计算机模拟来理解与正在进行的实验室实验密切互动的上皮组织的动态组织。关键的挑战是建立一个多尺度模型框架，能够弥合生化和生物物理亚细胞过程、细胞-细胞相互作用和由大细胞群体组成的组织的大规模多细胞特性之间的差距。这将需要设计新的数学近似技术，并应用专门适用于描述多细胞系统的高性能并行计算技术。

This project will use mathematical modelling and computer simulations to understand the dynamic organisation of epithelial tissues in close interaction with ongoing laboratory experiments. The key challenge is to develop a multi-scale modelling framework that is capable of bridging the gap between biochemical and biophysical sub-cellular processes, cell-cell interactions and the large scale multicellular properties of tissues composed of large cell populations. This will require the design of novel mathematical approximation techniques and application of high performance parallel computing technology specifically adapted for the description of multicellular systems.