Centre for REdefining antibiotic use to reDUce resistanCE and prolong the lives of antibiotics (REDUCE)

抗菌剂的无效剂量导致了抗菌素耐药性的升级，这种耐药性现在遍及医疗保健系统。重症监护病房和移植后的患者通常患有感染，更有可能治疗失败，出现耐药微生物。在这些研究中，我们将描述这些难以治疗的患者应该使用的抗菌药的剂量，并迅速分享这些药物用于常规临床。

Ineffective dosing of antimicrobials has contributed to the escalation of antimicrobial resistance which now pervades the healthcare system. Patients in the intensive care unit and post-transplant are examples of patients who commonly have infections, are more likely to fail treatment and have resistant microbes emerge. In these studies we will characterise the doses of antimicrobials that should be used in these difficult-to-treat patients and rapidly share these for routine clinical use.