Changing patterns of immunity following large scale malaria control programs in the South West Pacific

人们可以对疟疾产生部分免疫力，这需要持续暴露于感染才能维持。如果完全预防感染，人们可能会失去多年来培养的免疫力。在西南太平洋正在进行的重大疟疾蚊帐控制工作的背景下，我们将调查疟疾免疫状态的丧失或维持情况。这对疫苗开发和帮助我们确定反弹疾病的风险很重要。

People can develop partial immunity to malaria, which requires ongoing exposure to infection to be maintained. If exposure to infections is completely prevented, people can lose the immunity it has taken them years to develop. In the context of significant ongoing malaria bednet control efforts in the South West Pacific, we will investigate loss or maintenance of the malaria-immune state. This is important for vaccine development and to help us define risk of rebound disease.