Biomarkers of susceptibility and resistance to malaria following control programs in the South-West Pacific

西南太平洋控制计划后的疟疾易感性和耐药性生物标志物

• 批准号: nhmrc : 1052580
• 负责人: Dr Hayley Joseph
• 金额: $ 21.24万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/biomarkers-susceptibility-resistance-west-pacific/112286
• 关键词: Biomarkers; susceptibility; resistance; malaria; following

People can develop partial immunity to malaria, which requires ongoing exposure to infection to be maintained. If exposure to infections is completely prevented, people can lose the immunity it has taken them years to develop. In the context of significant ongoing malaria bednet control efforts in the South West Pacific, we will investigate loss or maintenance of the malaria-immune state. This is important for vaccine development and to help us define risk of rebound disease.

人们可以对疟疾产生部分免疫力，这需要持续暴露于感染才能维持。如果完全预防感染，人们可能会失去多年来培养的免疫力。在西南太平洋正在进行的重大疟疾蚊帐控制工作的背景下，我们将调查疟疾免疫状态的丧失或维持情况。这对疫苗开发和帮助我们确定反弹疾病的风险很重要。