The Impact of Transgenerational Racial Trauma on Epigenetic Modifications in the Mother-Infant Dyad during Pregnancy. Comparisons Between Caucasian and African American Populations
跨代种族创伤对怀孕期间母婴二元体表观遗传修饰的影响。
基本信息
- 批准号:10710037
- 负责人:
- 金额:$ 61.63万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-09-25 至 2027-06-30
- 项目状态:未结题
- 来源:
- 关键词:AccountingAddressAdultAfricanAfrican AmericanAfrican American populationAfrican ancestryAwarenessBiologicalBiological MarkersBlack raceCellsChildChildhoodChromatin StructureChronicCivil RightsCrowsDevelopmentDiscriminationDisparityEducationEnvironmentEpigenetic ProcessExposure toFetal DevelopmentFetal Growth RetardationFetusFutureGene ExpressionGenerationsGenetic TranscriptionGenomic DNAHealthHealth PromotionImmuneImmune System DiseasesImmune responseImmunityImmunologicsInfantInfant HealthInfant MortalityInflammationInflammation MediatorsInflammatoryInheritance PatternsInheritedInterventionLinkMaternal HealthMaternal-Fetal ExchangeModificationMononuclearMothersPathologyPatternPersonal SatisfactionPhenotypePhysiologicalPlacentaPlacentationPopulationPre-EclampsiaPregnancyPregnancy OutcomePregnant WomenPremature BirthPropertyRaceRiskShapesSignal TransductionSocioeconomic StatusStandardizationStressStructural RacismSurveysTissuesTrainingTraumaUmbilical Cord BloodUnited StatesVisionVoting RightWomanadverse outcomebisulfite sequencingcaucasian Americancohortcomparativecytokinedigitalexperiencefetalfetal immunitygenetic signaturegenome-widegenomic platformhealth disparityimmune activationimmunoregulationin uteroinfancyinfant morbidityinfant morbidity/mortalityinflammatory markermaternal stressmortalitymultiple omicsnano-stringneonateperceived stressracial disparityresponsesystemic inflammatory responsetranscriptometranscriptome sequencingtranscriptomicstransgenerational epigenetic inheritancetransmission processwhole genome
项目摘要
Project Summary
Structural racism and discrimination (SRD) have remained a historical legacy of the U.S. from the beginning of
enslavement of African populations in 1619 to the era of apartheid (“Jim Crow”), which ended with the Civil and
Voting Rights Acts. Hidden in plain sight is the biological impact of racial trauma. There is an increasing
awareness that SRD is a salient mechanism perpetuating racial gaps in health among African Americans. In
particular, studies have documented the impact of SRD on negative pregnancy outcomes, including higher rates
of preterm birth among African American (AA) women and higher rates of mortality among Black mothers and
infants. These racial disparities in maternal and infant health are pervasive even after accounting for socio-
economic status and education; and have been shown to persist transgenerationally, possibly via epigenetic
influences. In this study, we seek to investigate the impact of race and transgenerational SRD-related trauma
among AA women on distinct epigenetic modifications at the maternal-fetal interface that are linked to altered
immune cell development, activation, and signaling in the placenta and developing fetus. Studies suggest that
the placenta may be the gateway of maternal transgenerational epigenetic inheritance. Mounting evidence
suggests the effects of in utero epigenetic changes go beyond influencing the mother and the child, and are
carried forward through adulthood into germline, to the detriment of successive generations. Perturbed placental
epigenetics is associated with intrauterine growth restriction, preterm birth, and pre-eclampsia, which are the
drivers of infant mortality among AA. Studies demonstrate race is associated with placental inflammatory
pathology. In addition, high rates of stress due to transgenerational trauma have been associated with chronic
inflammation at the placenta and poor pregnancy outcomes. However, the biological properties that shape
disparities in pregnancy outcomes remain unknown. We hypothesize that SRD-related trauma is transmitted
across generations and manifests with epigenetic inheritance patterns that promote inflammation and innate
immune dysfunction in the placenta and fetus. Three specific aims have been proposed: 1) Evaluate the burden
of SRD on maternal stress, systemic inflammation, and epigenetic signatures among AA pregnant women; 2)
Perform comparative transcriptional, epigenetic, and immunological profiling of placentae from AA and CA
pregnant women to identify specific alterations associated with SRD-related stress; and 3) Investigate in utero
programming of immune responses and the inheritance of specific epigenetic signatures in AA neonates
exposed to maternal SRD-related stress. The biological impact of SRD on epigenetic alterations at the placenta
may contribute to increased vulnerability towards preterm birth and adverse outcomes in infancy and childhood.
These studies may inform future interventions to address such health risks and can promote the health and well-
being of at-risk mother-infant pairs.
项目总结
项目成果
期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Rana Chakraborty其他文献
Rana Chakraborty的其他文献
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{{ truncateString('Rana Chakraborty', 18)}}的其他基金
The Impact of Transgenerational Racial Trauma on Epigenetic Modifications in the Mother-Infant Dyad during Pregnancy. Comparisons Between Caucasian and African American Populations
跨代种族创伤对怀孕期间母婴二元体表观遗传修饰的影响。
- 批准号:
10523426 - 财政年份:2022
- 资助金额:
$ 61.63万 - 项目类别:
Next generation training in HIV research: Immunity in the First 1000 days in mother-infant dyads (TIGRIS)
下一代艾滋病毒研究培训:母婴二人最初 1000 天的免疫力 (TIGRIS)
- 批准号:
10594540 - 财政年份:2022
- 资助金额:
$ 61.63万 - 项目类别:
Next generation training in HIV research: Immunity in the First 1000 days in mother-infant dyads (TIGRIS)
下一代艾滋病毒研究培训:母婴二人最初 1000 天的免疫力 (TIGRIS)
- 批准号:
10471480 - 财政年份:2022
- 资助金额:
$ 61.63万 - 项目类别:
Mechanisms by which trophoblasts recruit T cells to the placental villi during maternal HIV and CMV co-infection
母体 HIV 和 CMV 合并感染期间滋养层将 T 细胞募集至胎盘绒毛的机制
- 批准号:
10080877 - 财政年份:2020
- 资助金额:
$ 61.63万 - 项目类别:
Mechanisms by which trophoblasts recruit T cells to the placental villi during maternal HIV and CMV co-infection
母体 HIV 和 CMV 合并感染期间滋养层将 T 细胞募集至胎盘绒毛的机制
- 批准号:
10223400 - 财政年份:2020
- 资助金额:
$ 61.63万 - 项目类别:
How maternal HCMV facilitates in utero transmission of HIV and impacts the developing fetal immune system during gestation
母体 HCMV 如何促进 HIV 子宫内传播并影响妊娠期间胎儿免疫系统的发育
- 批准号:
10005430 - 财政年份:2019
- 资助金额:
$ 61.63万 - 项目类别:
How maternal HCMV facilitates in utero transmission of HIV and impacts the developing fetal immune system during gestation
母体 HCMV 如何促进 HIV 子宫内传播并影响妊娠期间胎儿免疫系统的发育
- 批准号:
10245021 - 财政年份:2019
- 资助金额:
$ 61.63万 - 项目类别:
How maternal HCMV facilitates in utero transmission of HIV and impacts the developing fetal immune system during gestation
母体 HCMV 如何促进 HIV 子宫内传播并影响妊娠期间胎儿免疫系统的发育
- 批准号:
10201228 - 财政年份:2019
- 资助金额:
$ 61.63万 - 项目类别:
Determining how macrophages regulate immunity to Zika virus infection at the maternal-fetal interface
确定巨噬细胞如何调节母胎界面对寨卡病毒感染的免疫力
- 批准号:
9882936 - 财政年份:2017
- 资助金额:
$ 61.63万 - 项目类别:
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