Characterisation of eurl, a novel gene implicated in the etiology of abnormal brain development and intellectual disability

大约1%的澳大利亚人患有智力残疾，智力残疾可能是由于胎儿时期的基因异常引起的，例如基因表达的异常调节。我们已经确定了一种新的基因，称为eurl，它控制大脑组装以及神经元在大脑内形成功能连接的能力。我们将研究这种新基因如何控制大脑发育，并将eurl描述为学习和记忆的潜在治疗靶点。

Intellectual disability affects around one per cent of Australians, and can arise from genetic abnormalities during fetal life, such as through abnormal regulation of gene expression. We have identified a novel gene, known as eurl, which controls brain assembly as well as the ability of neurons to form functional connections within the brain. We will investigate how this novel gene controls brain development, and characterise eurl as a potential therapeutic target for learning and memory.