CHARACTERIZATION OF A NEW SUBTYPE OF AGGRESSIVE BREAST CANCER

人们在癌症基因组测序方面投入了大量精力，从而识别出与侵袭性亚型有关的基因。现在有必要确认这些基因的重要性，并将这些发现用于患者治疗。我们已经确定了一种新的癌症驱动因素，它控制着一种侵袭性的乳腺肿瘤，这种肿瘤可能通过碳/叶酸代谢发挥作用。我们的目标是绘制这些癌症的内部工作原理图，为这些患者设计有效的靶向药物。

Much effort has been invested in the sequencing of cancer genomes, leading to the identification of genes linked to aggressive subtypes. There is now a need to confirm the importance of these genes and to exploit these findings for patient therapies. We have identified a new cancer driver controlling an aggressive type of breast tumour which may act through one carbon/folate metabolism. We aim to map the inner workings of these cancers to devise effective targeted drugs for these patients.