Motor unit function: central descending and sensory reflex modulation

据了解，随着年龄的增长，肌肉力量降低，力量稳定性下降，功能能力下降。 这些变化的机制尚未明确阐明，直到最近才认识到性别差异。 因为有目的的运动仅仅是延长和缩短收缩的组合，所以必须了解在这些简单活动中激动剂和拮抗剂的MU活性。这些实验的总体目标是识别和确定中枢下行和感觉反射通路对运动神经元活动调制的贡献，以及对年轻和老年女性股四头肌力控制的后续影响。我们的工作假设是，感觉反馈和中央下行通路共同编码MU输出（招聘，放电率，同步和一致性的MU），但这种“集体编码”不同的收缩类型（等距，延长，缩短），并随年龄而改变。此外，由于男性和女性在功能能力和力量方面存在不同的年龄相关下降，并且这两个因素与MU活动密切相关，因此MU活动可能存在性别差异。 据我所知，迄今为止，MU活动尚未在健康的年轻和老年女性中进行过专门研究。 这些研究不仅将描述女性不等长股四头肌收缩期间激动剂和拮抗剂MU活动的特征，而且有助于我们理解感觉反射和脊髓上下行输入对MU活动的贡献以及与年龄相关的力控制变化。

It is understood that muscle strength is lower, force steadiness decreases and functional ability declines with advancing age.  The mechanisms of these changes have not been clearly elucidated and until recently gender differences were not recognized.  Because purposeful movement is merely a combination of lengthening and shortening contractions, it is imperative to understand MU activity of the agonist and antagonist during these simple activities. The overall objectives of these experiments are to identify and determine the contributions of central descending and sensory reflex pathways to the modulation of motor neuron activity and subsequent effect on force control in the quadriceps of young and old women. Our working hypothesis is that sensory feedback and central descending pathways work collectively to code MU output (recruitment, discharge rate, synchronization and coherence of MUs), however this 'collective coding' differs between contraction types (isometric, lengthening, shortening) and is altered with age. Moreover, because there are differential age-related declines between men and women in functional ability and strength and both of these elements are closely linked to MU activity it is plausible that a gender difference in MU activity might exist.  To my knowledge, to date, MU activity has not been purposely studied in healthy young and old women.  These studies will not only characterize agonist and antagonist MU activity during anisometric quadriceps contractions in women, but contribute to our understanding of the contribution of sensory reflex and supraspinal descending input on MU activity and age-related alterations in force control.