Can nanoparticles give an old iron chelator a new life? — Development of targeted polymeric nanoparticles with long half-lives to treat iron overload diseases

铁负荷失调（如地中海贫血）是一类重要的人类疾病。作为治疗这些疾病的一部分，需要去除铁，这通常是使用铁结合药物，即铁螯合剂。目前的螯合剂并不理想，因为副作用或繁琐的递送方法。该项目的目标是利用纳米技术开发更有效的运送螯合剂的方法，以提高其有效性和降低毒性。

Iron loading disorders (such as thalassaemia) represent an important class of human disease. As part of the treatment for these diseases, the iron needs to be removed and this is often done using iron-binding drugs known as iron chelators. Current chelators are not ideal due to side effects or onerous delivery methods. The goal of this project is to use nanotechnology to develop more effective ways of delivering chelators to improve their effectiveness and reduce toxicity.