Immune system involvement in skeletal muscle adaptation to contractile activity during human growth

大多数人会同意运动对儿童来说是必不可少的，但最近的统计数据告诉我们，五分之三的加拿大儿童不够活跃，无法达到最佳的生长和发育，这项提议将其定义为组织(例如骨骼肌)的健康功能。但问题是，1)最能促进儿童组织健康的运动类型尚不清楚，2)我们还不完全了解在人类成长过程中，运动转化为最佳组织功能的机制。但我们所知道的是，儿童的运动激活了免疫因子，使组织功能受益。我的研究计划的长期目标是澄清免疫系统在人类生长过程中将运动与肌肉适应联系起来的作用。我将首先确定儿童运动的类型，这将导致被认为对肌肉适应最佳的免疫因素的平衡。我怀疑模仿儿童游戏的运动将导致这一结果最佳平衡。接下来，我将利用儿童时期具有快速成长期的特点来研究成熟与运动的生长效应之间的关系。我预计，更多成熟的儿童将对运动表现出更强的生长相关反应，因为这是维持他们不断增长的生长速度所必需的。在对上述问题有了更清晰的理解后，我计划实施新的方法来揭示儿童肌肉细胞的属性，这些属性将与生长相关的过程与运动环境联系起来。我的研究项目提出了一个新的想法，即儿童的免疫系统有助于运动优化组织功能。在当今社会，大多数儿童还不够活跃，无法实现最佳的生长和发育，儿科运动科学的价值不容忽视。使用先进而强大的方法来揭示将运动转化为最佳生长和发育的机制，将是对该领域的重大贡献。最重要的是，该项目将产生对其他学科具有广泛重要性的信息，这些学科对肌肉如何适应健康和疾病的运动感兴趣。

Most people would agree that exercise for children is essential, but recent statistics tell us that 3 out of 5 Canadian children are not active enough for optimal growth and development, which this proposal defines as the healthy function of tissues (e.g., skeletal muscle).  The problems are that 1) the type of exercise that best promotes tissue health in children is unknown, and 2) we do not fully understand the mechanisms that translate exercise into optimal tissue function during human growth.  What we do know is that exercise in children activates immune factors with the capacity to benefit tissue function.     The long-term goal of my research program is to clarify the role of the immune system in linking exercise with muscle adaptation during human growth.  I will first determine the type of exercise in children that results in a balance of immune factors that would be considered optimal for muscle adaptation.  I suspect that exercise mimicking children's play will result in this optimal balance.  I will next make use of the fact that childhood is characterized by periods of rapid growth to examine how maturation is associated with the growth effects of exercise.  I expect that more mature children will exhibit stronger growth-related responses to exercise, as this is required to sustain their increased growth rate.  With a clearer understanding of the above issues, I plan to implement novel approaches to uncover the properties of children's muscle cells that link growth-related processes with an exercise environment.     My research program proposes a new idea that a child's immune system works to help exercise optimize tissue function.  In today's society when most children are not active enough for optimal growth and development, the value of pediatric exercise science cannot be neglected.  Use of sophisticated and powerful approaches designed to reveal mechanisms that translate exercise into optimal growth and development will represent a significant contribution to the field.  Importantly, this program will produce information with broad importance to other disciplines interested in how muscle adapts to exercise in health and disease.