Regulation and function of the protein tyrosine phosphatase TCPTP in mitosis

细胞周期是细胞繁殖的普遍过程，是所有生物生长发育的基础。细胞周期中最重要的事件涉及染色体DNA在S期的复制和有丝分裂时复制的DNA进入后代细胞的分离。有丝分裂在形态学上是细胞周期中最活跃的阶段，涉及许多由可逆蛋白磷酸化控制的过程的精确协调。蛋白磷酸酶在可逆蛋白磷酸化过程中起着重要作用，是有丝分裂所必需的。这项拨款提案的重点是了解蛋白磷酸酶在有丝分裂中的调节和功能。我们的研究将为有丝分裂的介导过程提供新的见解，并可能导致治疗癌症的替代策略的发展。

The cell cycle is a universal process by which cells reproduce and it underlies the growth and development of all living organisms. The most important events of the cell cycle concern the replication of chromosomal DNA during S phase and the separation of replicated DNA into progeny cells at mitosis. Mitosis is morphologically the most dynamic phase of the cell cycle and involves the precise coordination of many processes that are governed by reversible protein phosphorylation. Protein phosphatases play an important role in reversible protein phosphorylation and they are essential for mitosis. This grant proposal is focused on understanding the regulation and function of protein phosphatases in mitosis. Our studies will provide novel insight into processes mediating mitosis and may lead to the development of alternative strategies for treating cancer.