Laser techniques and applications in mass spectrometry spectroscopy and photonics

利普森团队将承担质谱学、分子光谱学和光子学方面的研究。在质谱学领域，利普森和他的同事将把短波长真空紫外线(VUV，波长在100 nm和200 nm之间)激光器连接到基质辅助激光解吸/电离(MALDI)质谱仪。中性分子在MALDI中的浓度远大于生成的初级MALDI离子的浓度。因此，用真空紫外激光对中性物质进行后电离将显著提高MALDI质谱分析的灵敏度数量级。利普森团队还将探索使用可见光吸收激光染料作为MALDI基质，并使用广泛可调的光学参数振荡器。他说，利普森团队将利用他们在单光子和多光子激光光谱学方面的专业知识来研究C2H2Br2等多原子小分子的高能电子态。这些光谱中分解的精细结构将使激发态分子几何结构首次得以建立。约翰·利普森和他的学生开发了用于制造光子带隙晶体的光学光刻的新方法。在本资金周期中，利普森团队将探索几个新的方向，包括：光刻制造能够在可见光到近红外光谱范围内工作的三维晶体；合成和表征含有硅、锗和锡部分的高指数聚合物抗蚀剂，以便可以直接一步制备活性晶体；制造量子点阵列；合成和表征包含β-BBO的非线性光子结构，以及生物膜图案化。

The Lipson group will undertake research in mass spectrometry, molecular spectroscopy, and photonics.    In the area of mass spectrometry, Lipson and co-workers will interface a short wavelength vacuum ultraviolet (VUV, wavelengths between 100 nm and 200 nm) laser to a matrix assisted laser desorption/ionization (MALDI) mass spectrometer. The neutral molecule concentration in the MALDI is much larger than that of the primary MALDI ions created. Post-ionization of the neutrals with a VUV laser will therefore significantly enhance the sensitivity of MALDI mass spectrometry by orders of magnitude. The Lipson group will also explore the use of visible light absorbing laser dyes as MALDI matrices with a widely tunable optical parametric oscillator.    The Lipson group will use their expertise in single and multiphoton laser spectroscopy to study the high energy electronic states of small polyatomic molecules such as C2H2Br2.  The fine structure resolved in these spectra will allow excited state molecular geometries to be established for the first time.    Lipson and his students have developed new approaches to optical lithography for the fabrication of photonic band gap crystals. In this funding cycle the Lipson group will explore several new directions including: lithographic fabrication of three-dimensional crystals that are capable of operating in the visible to near infrared spectral range; synthesis and characterization of high index  polymer resists containing Si, Ge and Sn moieties so that active crystals can be made directly in one step; fabrication of quantum dot arrays, synthesis and characterization of nonlinear photonic structures that incorporate beta-barium borate (BBO), and biofilm patterning.