Regulation of leukocyte lifespan by granzyme B and PI-9

为了对抗感染或癌症，身体产生称为细胞毒性淋巴细胞（CL）的特化细胞，其靶向并根除异常细胞。CL的数量在感染过程中急剧增加，并在感染后减少。这种人口减少是如何控制的还不完全清楚，但我们提出，CL用于杀死目标的蛋白质也触发CL的自杀后，它已经摧毁了一定数量的目标。如何做到这一点是这个项目的重点。

To fight infection or cancer the body produces specialized cells called cytotoxic lymphocytes (CLs) which target and eradicate abnormal cells. The number of CLs increases dramatically during infection, and decreases following infection. How this population decrease is controlled is not fully understood, but we propose that a protein used by the CL to kill targets also triggers suicide of the CL after it has destroyed a certain number of targets. How this is achieved is the focus of this project.