The relationship between vascular remodelling and mast cells in chronic asthma

众所周知，哮喘患者的气管壁增加了小血管的数量，这可能导致哮喘患者肺功能低下。这项拟议的研究使用了一种新的慢性哮喘绵羊模型来研究哮喘肺部气道壁血管的进行性变化。从我们的绵羊模型中获得的信息将有助于了解血管生长，从而最终有助于设计新的策略来治疗哮喘的影响。

It is known that the airwalls of asthmatics have increased numbers of small blood vessels which can contribute to poor lung function in asthma. The proposed research uses a novel sheep model for chronic asthma to investigate the progressive changes to the blood vessels in the airway walls of asthmatic lungs. The information gained from our sheep model will assist the understanding of blood vessel growth and thus ulitmately help in devising new strategies to treat the effects of asthma.