REVERSING EPITHELIAL TO MESENCHYMAL TRANSITION BY TARGETED EPIGENETIC EDITING IN BREAST CANCER

癌细胞在身体周围的扩散涉及细胞的变化，这些细胞允许它们迁移到血管，旅行然后侵入其他器官，这一过程被称为上皮间充质转化（EMT）。EMT还使细胞对我们最好的治疗方法不那么敏感。EMT包括开启激活这些变化的基因，关闭沉默这些变化的基因。我们将开发能够逆转这一过程的疗法，既减少癌症扩散，又使癌症治疗更有效。

Cancer cell spread around the body involves changes in the cells which allow them to migrate into blood vessels, travel and then invade other organs, a process called epithelial mesenchymal transition (EMT). EMT also makes cells less sensitive to our best treatments. EMT involves switching on genes that activate these changes and switching off genes that silence them. We will develop therapy that will reverse this process, both reducing cancer spread and making cancer treatment more effective.