The Role of Androgens In Female Physiology

本研究旨在建立一种独特的小鼠模型，以研究睾丸激素是否在女性生殖和一般健康中起重要作用。它将开发一种完全抵抗雄激素作用的生物状态的遗传小鼠模型。这样的老鼠和人类在遗传雄性中是众所周知的，但在遗传雌性哺乳动物中不会自然发生。通过创建这样一个小鼠系，该项目将能够首次详细测试睾丸激素是否在卵巢和其他女性组织（如骨骼、肌肉和大脑）的发育和功能中发挥重要作用。

This study is aiming to develop an unique mouse model in which to study the question whether testosterone plays an essential role in female reproductive and general health. It will develop a genetic mouse model for a biological state of complete resistance to the effects of androgens. Such mice and humans are well known among genetic males but this cannot occur naturally among genetic female mammals. By creating such a mouse line, this project will be able to test for the first time indetail whether testosterone has an impotant role in the development and function of the ovary and of other female tissues such as bone, muscle and the brain.