The role of arousal in the pathogenesis of obstructive sleep apnea and implications for novel therapeutic treatments

这项研究是一系列研究的一部分，旨在描述阻塞性睡眠呼吸暂停（OSA）的各种生理原因（表型）的相对重要性，并有可能根据这些特征产生个性化的新疗法。具体而言，本研究将探讨睡眠唤醒（短暂觉醒）在OSA中的作用，并探索操纵唤醒阈值的方法，作为某些OSA患者的新治疗方法。

This research forms part of a series of studies aimed at characterizing the relative importance of the various physiological causes (phenotypes) of obstructive sleep apnea (OSA) and has the potential to lead to individually tailored novel therapies according to these traits. Specifically, this proposed research will investigate the role of arousal from sleep (brief awakening) in OSA and explore methods of manipulating the arousal threshold as a new treatment approach for certain OSA patients.