The role of brain inflammation in leptin resistance

黑皮质素神经元控制体重并受瘦素调节。在肥胖症中，瘦素不能调节黑皮质素系统。我们将测试瘦素对黑皮质素神经元的作用是否受到肥胖小鼠中细胞因子信号传导抑制因子3（SOCS3）表达增加的限制。作为替代方案，我们将测试是否有血脑屏障的变化，或增加密度的支持和免疫细胞周围的黑皮质素神经元的肥胖小鼠，可能会限制这些神经元的输入。

Melanocortin neurons control body weight and are regulated by leptin. In obesity leptin cannot regulate the melanocortin system. We will test if leptin action on melanocortin neurons is limited by increased expression of suppressor of cytokine signalling 3 (SOCS3) in obese mice. As an alternative we will test if there are changes in the blood brain barrier, or an increased density of support and immune cells around melanocortin neurons of obese mice that might restrict inputs to these neurons.