The role of capsid protein nucleolar localisation in chikungunya virus: implications for vaccine development

基孔肯雅病毒(CHIKV)是一种全球广泛传播的蚊媒甲型病毒，能够导致相当大的人类发病率和死亡率。在没有CHIKV疫苗或抗病毒药物的情况下，本建议旨在通过研究CHIKV衣壳蛋白的宿主细胞核仁运输来合理设计CHIKV减毒活疫苗。这种疫苗有可能对其他澳大利亚地方性关节炎甲型病毒提供交叉保护，例如罗斯河病毒。

Chikungunya virus (CHIKV) is a globally widespread mosquito-borne alphavirus capable of causing considerable human morbidity and mortality. With no CHIKV vaccine or antiviral available this proposal aims to develop a live attenuated CHIKV vaccine, rationally designed by investigating the host cell nucleolar trafficking of CHIKV capsid protein. This vaccine has the potential to provide cross-protection against additional arthritogenic alphaviruses endemic to Australia such as Ross River virus.