Role of cyclin E2 in hormone-responsive breast cancer

雌性激素雌激素通过促进细胞繁殖来刺激乳腺癌的生长。我们发现细胞周期蛋白E2，它是控制细胞繁殖机制的一部分，对雌激素有反应。由于异常高水平的周期蛋白E2与乳腺癌早期复发有关，我们希望了解它在雌激素作用和乳腺癌中的作用，它的水平是如何控制的，以及过多的周期蛋白E2是否会干扰阻断雌激素作用的药物

The female hormone estrogen stimulates the growth of breast cancers by promoting cell reproduction. We have found that cyclin E2, which is part of the machinery that controls cell reproduction, responds to estrogen. Since abnormally high levels of cyclin E2 are linked with earlier relapse in breast cancer, we wish to understand what role it plays in estrogen action and in breast cancer, how its levels are controlled, and whether too much cyclin E2 interferes with drugs that block estrogen action