The Role of Eph-ephrin Interactions in Mediating Mesenchymal Stem Cell Commitment, Migration and Bone Fracture Repair

在澳大利亚，需要手术干预和康复治疗的骨折发生率越来越高。骨折愈合是一个复杂的过程，涉及不同骨细胞和免疫细胞的协调。我们的建议将确定哪些细胞-细胞接触分子介导正常骨骼生长和骨折修复过程中骨细胞的募集和发育。这项研究将有助于促进骨折修复和骨丢失疾病的治疗。

In Australia, there is an increasing incidence of fractures that require surgical intervention and rehabilitation therapy. Fracture healing is a complex process that involves the coordination of different bone and immune cells. Our proposal will identify which cell-cell contact molecules mediate bone cell recruitment and development during normal skeletal growth and bone fracture repair. This study will help advance therapies for fracture repair and diseases of bone loss.