Role of integrin signalling in breast and prostate cancer

整合素在控制乳腺发育和细胞功能中具有重要作用。在肿瘤进展过程中，整合素使癌细胞能够在转移过程中分离、增殖、迁移和存活。为了测试整联蛋白是否调节乳腺和前列腺肿瘤进展，将具有乳腺或前列腺特异性整联蛋白缺失的小鼠与经工程改造以发展癌症的小鼠杂交。将确定整联蛋白缺失对肿瘤生长和转移的影响。

Integrins have an essential role in the control of mammary gland development and cell function. During tumour progression, integrins enable cancer cells to detach, proliferate, migrate and survive during metastasis. To test whether integrins regulate breast and prostate tumour progression, mice with mammary or prostate specific integrin deletion will be crossed with mice engineered to develop cancer. The effects of integrin loss on tumour growth and metastasis will be determined.