The Role of Melanoma Tumour Antigen p97 (Melanotransferrin) in Melanoma Tumourigenesis.

黑色素瘤肿瘤抗原p97（黑素转铁蛋白）在黑色素瘤肿瘤发生中的作用黑素转铁蛋白（MTF）是铁转运蛋白转铁蛋白的同源物，并且是第一批充分表征的黑色素瘤肿瘤抗原之一。我们已发表的研究表明，MTF在体内黑色素瘤肿瘤发生中起着重要作用。在本提案中，我们将评估其是否与患者样本中的黑色素瘤进展相关，并检查其在黑色素瘤生长和转移中的作用。

The Role of Melanoma Tumour Antigen p97 (Melanotransferrin) in Melanoma Tumourigenesis Melanotransferrin (MTf) is a homologue of the iron transport protein, transferrin, and was one of the first well characterised melanoma tumour antigens. Our published studies have shown that MTf plays an important role in melanoma tumourigenesis in vivo. In this proposal, we will assess if it is associated with melanoma progression in patient samples and examine its role in melanoma growth and metastasis.