Role of the microglial adaptor molecule TYROBP in Alzheimer’s disease pathology
Role of the microglial adaptor molecule TYROBP in Alzheimer’s disease pathology
批准号:
nhmrc : 1147569
负责人:
Prof Jurgen Gotz
金额:
$31.3万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2018
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2018-01-01 至 2021-12-31
中文摘要
免疫激活是阿尔茨海默病(AD)大脑的特征;然而,它如何影响AD的进展尚不清楚。我们之前在AD大脑中的研究发现了免疫分子TYROBP,指出了该分子引发的有益和有害影响。在这里,我们旨在详细了解TYROBP是如何参与AD的,以及我们如何增强其益处并减少其意外行为。
英文摘要
Immune activation characterizes Alzheimer’s disease (AD) brains; however, how it impacts AD progression is not understood. Our previous studies in AD brains identified the immune molecule TYROBP, pointing at both beneficial and detrimental effects triggered by this molecule. Here, we aim to understand in detail how TYROBP is involved in AD and how we can enhance its beneficial effects and decrease its unintended actions.
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会议论文
SELECTIVE VULNERABILITY IN ALZHEIMER’S DISEASE AND RELATED DISORDERS: MECHANISM OF TAU PATHOLOGY
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批准号:nhmrc : 1003150
-
项目类别:Project Grants
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资助金额:$71.5万
-
财政年份:2011
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负责人:Prof Jurgen Gotz
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依托单位:
PATHOGENESIS OF ALZHEIMERS DISEASE AND RELATED DISORDERS: MECHANISM OF TAU PATHOLOGY
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批准号:nhmrc : 570920
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项目类别:NHMRC Project Grants
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资助金额:$19.74万
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财政年份:2009
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负责人:Prof Jurgen Gotz
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依托单位:
Comparative analysis of novel transgenic mouse models for brain and islet amyloidoses
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批准号:nhmrc : 512484
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项目类别:NHMRC Project Grants
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资助金额:$31.21万
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财政年份:2008
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负责人:Prof Jurgen Gotz
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依托单位:
Alzheimer's disease and related disorders: Mechanism of tau pathology in established and novel transgenic animal models
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批准号:nhmrc : 402596
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项目类别:NHMRC Project Grants
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资助金额:$28.21万
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财政年份:2006
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负责人:Prof Jurgen Gotz
-
依托单位:
国内基金
海外基金
CXCR4介导的小胶质细胞迁移在光感受器细胞变性中的作用及机制
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批准号:82371069
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项目类别:面上项目
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资助金额:49.00万元
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批准年份:2023
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负责人:李旌
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依托单位: