The role of NK cell receptors in tumor immunity and cancer therapy

白色血细胞淋巴细胞在癌症免疫和某些癌症治疗的活性中发挥重要作用。改善患者肿瘤中淋巴细胞功能的治疗显示出巨大的前景。然而，实际上对控制癌症功能的淋巴细胞受体家族一无所知。使用相关的癌症和患者肿瘤的小鼠模型，我们现在希望评估该受体家族在肿瘤免疫、治疗和逃逸中的相对重要性。

White blood cells lymphocytes have an important role to play in cancer immunity and the activity of some cancer therapies. Therapeutics that improve lymphocyte function in patient tumors are showing great promise. Yet, virtually nothing is known about one family of lymphocyte receptors that control function in cancer. Using relevant mouse models of cancer and patient tumors we now wish to assess the relative importance of this family of receptors in tumor immunity, therapy, and escape.