The role of the orbitofrontal cortex in disorders of response inhibition

我们将研究眶额皮质（OFC）在决策中的作用，特别是内侧与腹外侧眶额皮质的过度活跃对决策的影响。这些结构中的过度活跃与强迫症有关，并且与OFC不同区域的不同功能一致，我们开发并测试了一种新的假设，即这种障碍所特有的强迫和强迫的心理和神经基础。

We will investigate the role of the orbitofrontal cortex (OFC) in decision-making, particularly the effect of hyperactivity in the medial vs. ventrolateral orbitofrontal cortex on decision-making. Hyperactivity in these structures has been linked to obsessive compulsive disorder and, in line with the distinct functions of the different regions of OFC, we develop and test a novel hypothesis as to the psychological and neural bases of the obsessions and compulsions distinctive to that disorder.