The role of presynaptic inhibition in neuropathic pain
The role of presynaptic inhibition in neuropathic pain
批准号:
nhmrc : GNT1043933
负责人:
A/Pr Brett Graham
金额:
$31.08万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2013
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2013-01-01 至 2017-12-31
中文摘要
脊髓中的抑制性神经细胞被认为在控制疼痛和非疼痛刺激之间的相互作用方面发挥着重要作用。这一过程中的缺陷是导致神经病理性疼痛的重要症状--超常疼痛的原因。我们将利用基因技术(光遗传学)的最新进展来操纵和研究抑制神经细胞如何在正常和神经病动物的脊髓中分离触摸和疼痛信号。
英文摘要
Inhibitory nerve cells in the spinal cord are thought to play an important role in governing the interaction between painful and non-painful stimuli. Defects in this process underlie allodynia, an important symptom of neuropathic pain. We will use recent advances in genetic techniques (optogenetics) to manipulate and study how inhibitory nerve cells separate touch and pain signalling in the spinal cord of normal and neuropathic animals.
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会议论文
Excitatory interneurons: a sensory amplifier for pathological pain
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批准号:nhmrc : GNT1144638
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资助金额:$64.98万
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财政年份:2018
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负责人:A/Pr Brett Graham
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依托单位:
Excitatory interneurons: a sensory amplifier for pathological pain
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负责人:A/Pr Brett Graham
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依托单位:
Hypothalamic Control Of Motivated Behavior
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批准号:nhmrc : GNT1125478
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项目类别:Project Grants
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资助金额:$49.97万
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财政年份:2017
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负责人:A/Pr Brett Graham
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依托单位:
Hypothalamic Control Of Motivated Behavior
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资助金额:$34.07万
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依托单位:
Mechanisms underlying efferent feedback in the vestibular system
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项目类别:Project Grants
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资助金额:$49.15万
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财政年份:2016
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负责人:A/Pr Brett Graham
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依托单位:
Mechanisms underlying efferent feedback in the vestibular system
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批准号:nhmrc : 1105110
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资助金额:$33.9万
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财政年份:2016
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Spinal processing of sensory signals from the gut
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资助金额:$53.62万
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财政年份:2014
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负责人:A/Pr Brett Graham
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依托单位:
Spinal processing of sensory signals from the gut
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批准号:nhmrc : 1067146
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项目类别:Project Grants
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资助金额:$36.97万
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财政年份:2014
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负责人:A/Pr Brett Graham
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依托单位:
Microglia as primary drivers of stress-induced changes in neuronal connectivity
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批准号:nhmrc : 1066584
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项目类别:Project Grants
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资助金额:$31.73万
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财政年份:2014
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负责人:A/Pr Brett Graham
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依托单位:
Microglia as primary drivers of stress-induced changes in neuronal connectivity
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批准号:nhmrc : GNT1066584
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项目类别:Project Grants
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资助金额:$30.68万
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财政年份:2014
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负责人:A/Pr Brett Graham
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依托单位:
The role of presynaptic inhibition in neuropathic pain
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批准号:nhmrc : 1043933
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项目类别:Project Grants
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资助金额:$32.19万
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财政年份:2013
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负责人:A/Pr Brett Graham
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依托单位:
Spinal mechanism underlying arthritic joint pain
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批准号:nhmrc : 631000
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项目类别:NHMRC Project Grants
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资助金额:$28.77万
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财政年份:2010
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负责人:A/Pr Brett Graham
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依托单位:
海外基金