Role of sphingolipid signalling in hepatic insulin resistance and its application in prediction of risk for type 2 diabetes and prediabetes

2型糖尿病预计将在未来几十年达到流行病的程度。前驱糖尿病通常未被发现，并构成一个需要早期干预的主要公共卫生问题，因为大多数前驱糖尿病患者会发展为T2D。我们已经确定了一种在胰岛素信号传导中起重要作用的酶。这种酶的水平或活性可能是糖尿病前期状态的潜在生物标志物，也可能用作靶标

Type 2 diabetes is expected to reach epidemic proportions in the coming decades. Prediabetes is usually unrecognized and constitutes a major public health concern that needs earlier interventions, because the majority of prediabetic subjects proceed to T2D. We have identified an enzyme that plays an important role in insulin signalling. The possibility is that the level or activity of this enzyme is a potential biomarker of the prediabetes state and could be also used as a target